Comparison of the predictive value of progesterone‐related indicators for pregnancy outcomes of women undergoing the short‐acting GnRH agonist long protocol: a retrospective study

Abstract Background There are many progesterone (P) elevation-related indicators for predicting pregnancy outcomes, including the serum P, P-to-oestradiol ratio (P/E 2 ), P-to-follicle index (PFI), and P-to-mature oocyte (PMOI); however, due to inconsistencies in study populations controlled ovarian hyperstimulation (COH) protocols among studies, these controversial. Moreover, no researchers have included four commonly used one compare their predictive efficacies. The objective of this was value P-related outcomes women undergoing short-acting GnRH agonist long protocol. Methods A total 612 infertile IVF/ICSI were recruited study. Serum samples obtained on morning HCG injection P E measurements. Transvaginal ultrasound performed determine follicle count (≥ 14 mm diameter). number mature oocytes observed embryo laboratory after retrieval. Results In cases < 2.5 ng/ml, there significant difference level or P/E between pregnant group non-pregnant group. PFI PMOI significantly lower than those According stratified analysis response, only PMI normal response women. To patients divided into groups. good-quality rate clinical highest Group (low low PMOI) lowest D (high high PMOI). two groups with discordant PMOI, namely B C PMOI), not different. Conclusions had equal Each centre can choose according actual situation practice establish individual cut-off values based own hormonal